Asymmetric dimethylarginine levels in patients with diabetic nephropathy
نویسندگان
چکیده
Diabetic nephropathy is a major cause of endstage renal disease worldwide and is characterised by persistent albuminuria, functional and structural changes in the glomerulus. Patients with diabetes mellitus with kidney damage are at higher risk of fatal and nonfatal cardiovascular events.1 Evidence shows that nitric oxide pathway plays an important role in the development of vascular complication in diabetes. Nitric oxide levels are decreased in diabetic nephropathy due to increased asymmetric dimethyl arginine (ADMA) which is a competitive inhibitor of nitric oxide synthase.2 Microalbuminuria is the first detectable sign of renal dysfunction in diabet ic patients. Both ADMA and microalbuminuria represent markers of endothelial dysfunction which increases the cardiovascular risk in these patients. Therefore this study was designed to study asymmetric dimethyl arginine levels in patients with diabetic nephropathy and its association with proteinuria.
منابع مشابه
Dysregulation of dimethylargininedimethylaminohydrolase/asymmetric dimethylarginine pathway in rat type II diabetic nephropathy
An impaired generation of nitric oxide has been associated with diabetic renal disease. In order to elucidate the underlying molecular mechanisms into how nitric oxide synthesis is impaired in diabetic renal disease, we examined changes in activities and expressions of some renal enzymes involved in nitric oxide production during the development of diabetic nephropathy in type II diabetic Otsuk...
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